Open Login Screen

Bhringraj

89.png
Eclipta alba is commonly known as bhringraj in India. It also has a synonym as Eclipta prostata. It is a plant belongs to the family Asteraceae. It grows commonly in moist places as a weed all over the world. It is widely distributed throughout India, China, Thailand, and Brazil.
Favoured:
0

Listing Details

Botanical Names
Eclipta alba
Indian Names
Sanskrit : Ajagara, Bhringaraja, Kesaraja Bengali : Keshori, Kesuti Gujarati : Bhangra, Kaluganthi, Dodhak Hindi : Bhangra Malayalam : Kyonni Marathi : Maka Kannada : Garagadasoppu Tamil : Kayanthakora Telugu : Guntagalijeru
Chemical Constituents
The herb Eclipta alba contains mainly coumestans i.e. wedelolactone (I) and demethylwedelolactone (II), polypeptides, polyacetylenes, thiophene-derivatives, steroids, triterpenes and flavonoids. Major constituents of it include Coumestan derivatives, demethyl-wedelolactone and Wedelolactone- about 1.6%. Other constituents includes thiopene derivatives e.g. Ecliptal; saponins viz., hentriacontanol, 14-heptacosanol; flavonoids e.g. Luteolin-7-O-glucoside; alkaloids and polypeptides.
Pesticide Limits
A limit for pesticide is one of the major issues in standardization of medicinal plants and products in view of the worldwide widespread use of pesticides in cultivated plants. The presence of pesticides in extracts increase the health risk by many folds. The pesticides can be extremely irritant on skin as well as in the internal organs, it is essential to monitor its concentration as a part of GMP. Various analytical methods for the quantitative determination of pesticides by gas chromatography coupled with mass-spectrophotometer are in use. Konark Research Foundation (KRF), a NABL certified lab is well equipped with the latest technology and instruments and monitors the pesticide limit as part of its GMP.
Chromatographic Profile
From the pharmacopoeial perspective, a better quality control of raw material can be achieved by specifying a quantitative test procedure for the determination of the range or a minimum content by specifying a quantitative test procedure for the determination of the range or a minimum content of the marker substances or the ‘active’ ingredient. A chromatographic finger profile represents qualitative/ quantitative determination of various components present in a complex plant extract irrespective whether or not their exact identity is known. Thin layer chromatographic technique is the simplest and least expensive method that provides plenty of information on the composition of raw herbs and its preparation. For quantitative analysis of active ingredients or marker substances with simultaneous separation and detection High Pressure liquid chromatography is the best technique. We use the latest model of HPLC for all its analysis.
Limits of Impurities
A test requirement for foreign organic matter would ensure the extent of contamination of extraneous matters such as filth and other parts of botanicals not covered by the definition of the herbal drug.Since sand and soil are predictable contaminants of botanicals, test requirements for ‘total ash’, water soluble ash’, ‘acid soluble ash’, residue on ignition and sulphated ash would be expected to limit such contaminants.Test requirement for heavy metals in botanical raw material are probably more relevant for parts of plants growing under ground than for the aerial parts of the plant. The presence of high levels of minerals interacts with the final product there by affecting its keeping quality.
Microbial Limits
If the raw herb is to be used directly without boiling in water prior to consumption, restrictive limits on microbial contaminants are required for pathogens such as Salmonella sp. Enterobacter and E.coli which are causative agent for various gastro-intestinal diseases. A lower level of yeasts and molds and a limit on total aerobes are considered appropriate in plant material for topical use. The presence of aflatoxins detected by chemical means is generally independent of the number of viable molds that are detected using microbiological methods. Aflatoxins in microgram quantity are capable of giving serious hypersentivity reactions which can be extremely harmful to human health.
Pharmacology
Eclipta alba is used as an important constituent in Ayurveda and Yunani medicines. Bhringraj is very good hepato protective agent. Wedelolactone an important active constituent of Eclipta alba possesses a wide range of biological activities and used to treat hepatitis and cirrhosis as an antibacterial and anti-hemorrhagic agent. Recent studies have shown that it has a profound antihepatotoxic activity. A cardio depressant activity was also observed in it when used for hepatic congestion. The liver problems like hepatomegaly can be resolved with the help of bhringraj. Eclipta alba is widely used in India as a cholagogne and deobstruent in hepatic enlargement, for jaundice and other ailments of the liver and gall bladder. It can also be used to treat insomnia, and other mental disorders like stress, anxiety and depression. It is also used to treat dermatitis and various skin problems.
Health Benefits
Eclipta alba is generally known as Bhringraj. It is widely used in the Indian traditional system of medicine. The leaf extract is considered as a powerful liver tonic, rejuvenative, and especially good for the hair. The fresh juice of leaves is used for increasing appetite, improving digestion and as a mild bowel regulator. It is commonly used in viral hepatitis to promote bile flow and protect the parenchyma. The plant has a reputation as an antiageing agent in Ayurveda. Eclipta alba is used as a general tonic for debility. It is useful in inflammations, eye diseases, leucoderma, heart and skin diseases, etc. Eclipta alba is a source of coumestan-type compounds used in phyto pharmaceutical formulations of medicines prescribed for treatment of cirrhosis of the liver and infectious hepatitis.
Application in Cosmetics
Bringraj has many medicinal properties and can cure number of disorders but it also have got some interesting cosmetic values. Bhringraj is very beneficial for hair, since long period it has been used in hair care. It improves the blood circulation of scalp thus strengthen the root hairs make them stronger and healthy. It prevents the hair fall. It has an anti-inflammatory effect. It is mainly used as an ayurvedic tonic for hair care. It is mainly used for dying the hairs.
Research References
1. www.pubmed.gov Pubmed, a wellknown site has listed important studies going on around the world in various universities. These include….. 1. Impact of the aqueous extract of Eclipta alba on maternal aggression in rats.(Banji D, Banji OJ, Annamalai AR, Shanthmurthy M.Pak J Pharm Sci. 2010 Apr;23(2):138-42.PMID: 20363689). 2. Eclipta alba extract with potential for hair growth promoting activity. (Datta K, Singh AT, Mukherjee A, Bhat B, Ramesh B, Burman AC.J Ethnopharmacol. 2009 Jul 30;124(3):450-6. Epub 2009 May 28.PMID: 19481595). 3. Inhibition of snake venoms and phospholipases A(2) by extracts from native and genetically modified Eclipta alba: isolation of active coumestans.(Diogo LC, Fernandes RS, Marcussi S, Menaldo DL, Roberto PG, Matrangulo PV, Pereira PS, França SC, Giuliatti S, Soares AM, Lourenço MV.Basic Clin Pharmacol Toxicol. 2009 Apr;104(4):293-9.PMID: 19320636). 4. Evaluation of antiaggressive activity of Eclipta alba in experimental animals.(Lobo OJ, Banji D, Annamalai AR, Manavalan R.Pak J Pharm Sci. 2008 Apr;21(2):195-9.PMID: 18390451). 5. Investigation on the effect of Eclipta alba on animal models of learning and memory.(Banji O, Banji D, Annamalai AR, Manavalan R.Indian J Physiol Pharmacol. 2007 Jul-Sep;51(3):274-8.PMID: 18341224). 6. Anti-malarial activity of Eclipta alba against Plasmodium berghei infection in mice.(Bapna S, Adsule S, Shirshat Mahendra S, Jadhav S, Patil LS, Deshmukh RA.J Commun Dis. 2007 Jun;39(2):91-4.PMID: 18338686). 7. Oral administration of Eclipta alba leaf aqueous extract enhances the non-specific immune responses and disease resistance of Oreochromis mossambicus.(Christybapita D, Divyagnaneswari M, Michael RD.Fish Shellfish Immunol. 2007 Oct; 23(4):840-52. Epub 2007 Mar 24.PMID: 17499515). 8. Diuretic, hypotensive, and hypocholesterolemic effects of Eclipta alba in mild hypertensive subjects: a pilot study.(Rangineni V, Sharada D, Saxena S.J Med Food. 2007 Mar; 10(1):143-8.PMID: 17472478). 9. Antihyperglycemic activity of Eclipta alba leaf on alloxan-induced diabetic rats.(Ananthi J, Prakasam A, Pugalendi KV.Yale J Biol Med. 2003; 76(3):97-102.PMID: 15369623). 10. Optimization of wedelolactone accumulation in shoot cultures of Eclipta alba.(Jayathirtha MG, Mishra SH.Indian J Exp Biol. 2003Dec; 41(12):1476-8.PMID: 15320508). 11. The protective effect of Eclipta alba on carbon tetrachloride-induced acute liver damage.(Ma-Ma K, Nyunt N, Tin KM.Toxicol Appl Pharmacol. 1978 Sep; 45(3):723-8. No abstract available. PMID: 725927). 12. Hepatoprotective effects of Eclipta alba on subcellular levels in rats.(Saxena AK, Singh B, Anand KK.J Ethnopharmacol. 1993 Dec; 40(3):155-61.PMID: 8145570). 1. Indian Herbal Pharmacopoeia (Revised New Edition 2002). 2. Standardization of Botanicals, Volume 2- By Dr. V. Rajpal. 3. www.pubmed.gov
Attachment