A preliminary phytochemical screening of the hydroalcoholic extract of the leaves of Sida cordifolia demonstrated the presence of alkaloids, steroids, flavonoids and saponins. Chemical studies of the leaves of this plant revealed the presence of ephedrine, pseudoephedrine (vasoconscrictor), vasicinone, vasicine and vasicinol (bronchodilators) (1). The roots and stems contain the alkaloid ephedrine, normally observed in the different varieties of the gymnosperm genus Ephedra. Recent analyses have revealed that ephedrine and pseudoephedrine constitute the major alkaloids from the aerial parts of the plant, which also show traces of sitosterol and palmitic, stearic and hexacosanoic acids. The flavones: 5,7-dihydroxy-3-isoprenyl flavone and 5-hydroxy-3-isoprenyl flavone, β-sitosterol and stigmasterol have been isolated from the plant. The analgesic alkaloid (5′-Hydroxymethyl-1′-(1, 2, 3, 9-tetrahydro-pyrrolo [2, 1-b] quinazolin-1-yl)-heptan-1-one) has also been found. Sterculic, malvalic and coronaric acids have been isolated from the seed oil, along with other fatty acids.