Vitex nigundo has been claimed to possess many medicinal properties. The Vitex negundo plant is bitter, acrid, astringent in taste and cephalic, stomachic, antiseptic, thermogenic, depurative, rejuvenating, and ophthalmic in action. It is useful in the treatment of bronchitis, asthama and enlargement of spleen. Roots of this plant are tonic, febribuge, antirheumatic, diuretic, expectorant in action. Leaves of Vitex nigundo have been investigated for its anti-inflammatory activity. Fresh leaves of Vitex nigundo have been suggested to possess anti-inflammatory and pain suppressing activities possibly mediated via antihistaminic, membrane stabilizing and antioxidant activities. It has also been investigated for an anti-inflammatory, anticonvulsant, hepatoprotective and bronchial relaxant actions. Leaves of Vitex negundo are anti inflammatory, antipyretic, febrifuge, bronchial smooth muscle relaxant, anti arthritic, antihelmintic and vermifuge in action.