Cissus quadrangularis has been used by common folk in India for promoting the fracture healing process. Cissus quadrangularis, a plant that has been customarily used in the Indian subcontinent to hasten the process of healing in bone fractures. The plant extract serves as a rich source of calcium ions, which when reacted with CO2, leads to the formation of calcite crystals of highly irregular morphology indicating that bioorganic molecules present in the extract modulate the crystal morphology. In Cameroon, the whole plant is used in oral re-hydration, while the leaf, stem, and root extracts of this plant are important in the management of various ailments. Cissus quadrangularis is well known for the treatment of gastric disorders in traditional medicine, owing to its rich source of carotenoids, triterpenoids and ascorbic acid, and has received considerable attention regarding its role in human nutrition. In the search of new potential antiulcer agents, the present study evaluated the ethanol extract of Cissus quadrangularis (CQE) against the gastric toxicity induced by aspirin in rats.
It has also been used to treat obesity and associated oxidative stress. A weight loss supplement containing Cissus quadrangularis with several dietary supplements (green tea, soy, and selenium, chromium, and B vitamins) was evaluated in an 8-week clinical trial. The supplement helped to reduce body weight by 4-8% where as a placebo reduce it by 2.4% a clinically significant weight loss (5). It has also been used to treat osteoporosis, asthma, cough, hemorrhoids, and gonorrhea. In the traditional medicinal systems of India it has been reported to possess not only bone fracture healing.