Phytochemically the root bark extract contains D-mannitol, stigmasterols and three triterpenoids- oleanolic acid, queretaric acid and cerratagenic acid. Leaf extract contains stigmasterol, spinasterol, luteolin, luteolin 7-0 glucoronide, apigenin, baicalin and scutellarin 7-0 glucoronide.
From the bark the sapogenin mixture contains three major triterpenoid constitutent’s oleonolic acid, queretaroic acid and serratagenic acid. The root bark yields a glycoside material, phenolic in natures. D – Mannitol is isolated from the bark with a yield of 10.9 % . The powdered stem contains D- mannitol, D- glucoside of sitosterol, sitosterol and cetyl alcohol. Alcoholic extract and saponin isolated from root bark caused release of histamine from lung tissue. The plant is reported to contain β-sitosterol, 24(S)-ethylcholesta-5, 22, 25-trien-3 β-ol, 5-hydroxy-7,4'-dimethoxy flavone, luteolin, apigenin, scutellarien, ursolic acid and two iridoid glucosides namely 7 β-coumaroyloxyugandoside and 7 β-cinnamoyloxyugandoside. The vast ethno medical uses of the plant inspired us to investigate the antioxidant properties (1).
Preliminary phytochemical screening revealed presence of Flavonoids, Saponins and Sterols. Beta-sitosterol, 24(s)-ethyl cholesta-5, 22, 25-trien-3 beta-ol, 5 hydroxy-7, 4’-dimethoxy flavone, luteolin, apigenin, scutellarine and urosolic acid were reported in the stem of Clerodendrum serratum (2).