It has been reported to possess antimicrobial, anti amoebic, anti diarrheal, anti plasmodial, hepatoprotective, immuno-modulatory, anticancer, anti-asthmatic, free radical scavenging, antioxidant, analgesic, anti-inflammatory, anti-ulcer, anti-fertility and wound healing activities. In other parts of the world, it is used as a source cure against bacterial infection, malarial fever, toothache, rheumatism, snakebite, dysentery, bowl disorder, etc. The bark is bitter, astringent, digestive, laxative, anti-helmintic, antipyretic, stomachic, cardiotonic and tonic. The bark extract has been reported to posses’ anti-plasmodial, immuno-stimulant, anticancer effect and is also hepatoprotective.
In India the bark of Alstonia scholaris is used solely for medicinal purposes, ranging from malaria and epilepsy to skin conditions and asthma. Extracts prepared from the plant has been reported to possess cytotoxic activity. An ethanol extract of the bark of Alstonia scholaris enhanced the anticancer activity of berberine in the Ehrlich ascites carcinoma-bearing mice. This extract also showed cytotoxic activity to HeLa cells. It contains echitamine and loganin as major compounds and could potentially be used as an anti-irritation agent. The bark of the plant is most extensively used part and is reported to have anticancer properties by the people of different cultures and civilizations like India. The alcoholic extract of Alstonia scholaris has been recently reported to be antineoplastic and chemo preventive (2).