Celastrus paniculatus is generally known as Malkanguni or Jyotismati in India. It is a shrub widely used in Ayurdevic medicine in India. Various properties are attributed to the aerial parts of the plant, but seeds of Malkanguni and seed oil are more generally used in Indian system of medicine as found to be more beneficial as compared with the other parts. Celastrus paniculatus seeds and oil have long been regarded in India as beneficial to the intellect and memory. The seeds are hot, bitter, dry, and acrid in taste. It is said to cure joint pain, rheumatism, and weakness. The seed oil enriches the blood, cures abdominal complaints, stomachic, tonic, treats cough, asthma, leprosy, headaches, leucoderma. Aqueous extracts of Celastrus paniculatus seed have been reported to improve learning and memory in rats. In addition, these extracts were shown to have antioxidant properties, augmented endogenous antioxidant enzymes, and decreased lipid peroxidation in rat brain.